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ed and large numbers of studies were conducted, primarily with LSD. These investigators sought to discover the receptor binding sites for hallucinogenic compounds in the brain and to understand the mechanisms underlying the genesis of psychedelic visions. Today, we still lack a sound theoretical framework able to explain the relationship between chemical compounds and the manifestation of their psychoactivity. Even though basic research is certainly important, its methods, unfortunately, are often a function of a rather one-sided pharmacological approach to investigating the effects of psilocybin, LSD and mescaline - an approach that is, in fact, too narrow to address the remarkably unusual nature of these substances and their effects. Misunderstandings between pharmacologists and toxicologists on the one hand and psychiatrists and psychologists on the other can often be traced all the way back to the 1950's, creating a legacy of disputes and arguments that have yet to be resolved. S. Grof undertook the tedious task of analyzing 5,000 experimental LSD protocols in an effort to isolate "absolute" symptoms that are reported or occur all of the time. His results were negative. According to Grof, hallucinogenic substances are non-specific triggers causing a sequence of altered states of consciousness, which do not fit the syndrome labeled "toxic psychosis". Rather, it is the individual's personality, along with the experimental setting that significantly shape the nature of the psychedelic experience. This view is shared by a majority of experts with considerable experience in conducting psychedelics-assisted psychotherapy. Even "real" somatic symptoms, such as nausea or vomiting, can often be controlled through psychological intervention techniques administered by trained professionals. A Plethora of Names The broad range of possible experiences inspired the use of labels other than "hallucinogens", with widely differing semantic connotations: entheogens, psychedelics, illusionogens, psycholytics, psychomimetics, psychodysleptica, psychoemetics and others. "Phantastica" (Lewin) is the oldest label ever used to describe this class of substances. This term successfully evokes dream-like, fanciful aspects of the experience, as well as the potential for euphoric and dysphoric emotional overtones. More recent terminology often says more about semantic biases of those who use the labels than about any factual, objective characteristics of the alkaloids they refer to. Accordingly, official antidrug propaganda since the 1960's has disparaged "psychedelics" as excessively glamorous and too positive a label, as the term was popular among Timothy Leary's fans and supporters. When used in low doses or for the first time, these substances are most likely to bring about a kind of magical transformation of surroundings, with a heightened ability to perceive subtle differences along the color spectru LS 1058 SEEDS 1058 LS
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